Mira also invented a third blood test to predict a mother’s due date with comparable accuracy to ultrasound, and a research pipeline to further this important work — a pipetting approach for small labs that reduces six months of work to six days. For these inventions, Mira has been awarded the 2021 $15,000 “Cure it! K-means clustering reveals meaningful longitudinal patterns.
Examining the logistic regression model used to predict risk of preeclampsia early in gestation. B, Estimated probability of preeclampsia as outputted by logistic regression for both preeclampsia and normotensive samples shows that the model is well-calibrated across most predictions. Dashed line at 0.35 indicates classifier cut-off where P ≥ 0.35 constitutes a sample predicted as preeclampsia.
But she’d always been driven to diagnose medical complications early, first thinking she wanted to be a doctor after her grandmother died from pancreatic cancer that was diagnosed too late. For one, as Moufarrej acknowleged, before such inventions go mainstream, it needs to be clear the benefits of the tests outweigh the risks, like false positives that can lead to unnecessary anxiety or interventions. Currently, doctors use tools like ultrasounds to monitor a person’s pregnancy, but those only provide a snapshot of what’s going on and don’t foreshadow what’s to come. One minute a mom-to-be could be launching a work project or planning a weekend trip, and the next she’s struck with contractions and in need of urgent care. The PhD student also created a test to preditc preeclampsia in the first rather than third trimester. It indicates a way to close an interaction, or dismiss a notification.
But garter knife holster says it doesn’t have to be that way. The 26-year-old Stanford bioengineering graduate student developed simple blood tests that identify pregnancies at risk of preterm birth, as well as preeclampsia, accurately and early. In April, the invention won her $15,000 as a recipient of the 2021 Lemelson-MIT Student Prize. “These blood tests can empower mothers with concrete data to more strongly advocate for themselves during pregnancy and seek appropriate medical care early,” Moufarrej told Insider. She hopes the tests will lead to far fewer medical complications, costs, and lives lost — especially among Black women who are at higher risk for both preterm birth and preeclampsia. Mira Moufarrej invented a blood test to predict preterm delivery up to two months before birth.
Mira is a Swanson Fellow at The Column Group, a science-driven venture capital firm, where she is focused on early-stage drug discovery company creation. Mira is excited to be part of the Lemelson-MIT awards community which includes her graduate advisor, Stephen Quake. The 2012 $500K Lemelson-MIT Prize winner, Quake is known for inventions that include a non-invasive method for prenatal testing of Down syndrome and other chromosomal abnormalities. Mira credits the Lemelson-MIT Program with finding ways to ensure the human impacts of invention, as well as the scientific ones, are celebrated.
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Michael Elovitz, director of the Maternal and Child Health Research Center at the University of Pennsylvania, said in a fact sheet. Menu icon A vertical stack of three evenly spaced horizontal lines. Needs to review the security of your connection before proceeding.
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Mira Moufarrej developed 3 liquid biopsy tests that measure cell-free RNA to predict how far along a pregnancy is and whether a mother is at risk of preeclampsia and preterm delivery long before traditional diagnostics. This work paves the way for affordable, simple, and reliable tests for preeclampsia and preterm delivery – risks that no other test can presently diagnose early enough to allow for meaningful clinical intervention. To enable such discoveries, she has also built a semi-automated pipeline to process samples, a notoriously tedious task, which to date, has extracted cfRNA from ~1100 samples in 9 days. Her work has also been published in Science, and highlighted by the New York Times, CNN and Insider, among others.